Effects of 1p-LSD

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Brief intro to 1p-LSD

1p-LSD, short for 1 Propionyl Lysergic Acid Diethylamide is the hallucinogenic, psychedelic drug that belongs to the family of lysergamide. This substance has almost no history of human use. This substance has never been reported in any formal scientific literature making it unknown to the public and the academics.

Surprisingly it is structurally similar to LSD and ALD 52 which suggest it has an identical effect profile as well. With the lack of research related to this substance, every argument related to the pharmacology of this drug is completely according to its structure and the subjective effect that are not different from other such lysergamides.

In the early months of 2015, 1p-LSD got its legal alternative LSZ and LSD, and it was marketed through online chemical vendors who were selling it. This compound as mainly sold in blotter sheet tabs. It was marketed as a research chemical that made it easy to sell it legal, although it was sold for human consumption


According to its molecular structure, it belongs to lysergamide family. It is quite analogous to LSD, and it has been named for its propionyl group that is bound to the nitrogen of polycyclic indole group. The propionyl consists of carbonyl chain that is bound to an amino group. 1p-LSD contains a polycyclic group that features the bicyclic Hexahydro indole bound to its quinolone bicyclic group. At carbon 9 of quinoline, the n-diethyl carboxamide becomes bound.

Right now it is in the grey market area that makes its purchase a bit unsafe.


It acts as the partial agonist of 5 HT2A. Psychedelic effects come from efficacy at 5HT2A receptors. The role of such interactions and how these result in psychedelic experience always remain elusive.

Moreover, it has been theorized that 1p-LSD is a prodrug to LS. It shows only 35% potency of LDS in mice. The LSD is detected with the help of LC-MS when the 1p-LSD is incubated in Human Serum. This means that 1p-LSD doesn’t only acts as a prodrug for LSD but also, it directly acts as serotonin receptor against its very own rights.

Subjective Effects

The subjective effects of 1p-LSD are similar to those structurally related to it. The differences are minuscule that are negligible and virtually indistinguishable from each other. As comparing to other psychedelics which includes LS and Psilocin, the 1p-LSD proves to be even more stimulating and fast paced when it comes to a specific type of its physical and cognitive effects. The effects are listed blow that are based on the subjective effects index and personal experience of some subjects. The listed effects rarely occur and only once. However if the dosage is heavy, it can lead to severe cases.

Physical Effects

  • Tactile Sensations
  • Stimulation
  • Bodily controlled enhancement
  • Nausea
  • Tactile improved
  • Pupil Dilation
  • Increase heart rate

Cognitive Effects

  • Current mind state enhancement
  • Thought acceleration
  • Novelty enhancement
  • Immersion enhancement
  • Time distortion
  • Ego death
  • Mindfulness
  • Thought loops
  • Delusions
  • Feeling interdepent opposites
  • Conceptual thinking
  • Self-design feeling
  • Wakefulness
  • Creativity enhancement
  • Though disorganization
  • Spiritual enhancement
  • Personal bias enhancement

Auditory Effects

  • Distortions
  • Hallucination
  • Enhancement
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March 14, 2016 |

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