What is Acetildenafil and its Effects
The Acetildenafil, also known as Hongdenafil is defined as a structural analogue of Viagra. According to studies, it has been found out that Acetildenafil acts as a PDE5 inhibitor, just like Viagra. The fact is, this compound is a great addition to people who are studying effects of Viagra. However, Acetildenafil is not yet licensed for any form of Vivo (inside of a living organism) research. Due to the fact it has a strong chemical resemblance to Viagra, it binds in similar ways to receptors in Vitro (outside of a living organism).
The analogue of Acetildenafil was first discovered as an extract of pre-mixed bulk powder. As the story goes, it was intended to be encapsulated and labeled as a dietary product. Its structure was analyzed by different analyses such as NMR, HR-ESI, MS, ESI-Msn and even FTIR Analyses. Owing to the inclusion of hydroxyl group in ace iDEN fil, the detected compound was called Hydroxyacetildenafi.
What is it used for?
The Acetildenafil is strictly for research purposes at the moment. According to research, it has been found that Acetildenafil can be used in conjunction with other PDE5 inhibitors including Sildenafil as long as home office license is held for it. The competitive ligand binding assays can be performed using this compound to learn about its affinity.
The solutions that contain cGMP specific phosphodiesterase type 5 can be used for determination of efficacy and binding site profile of Acetildenafil. The array of in vitro research opportunities exists for the novel inhibitor.
The Acetildenafil is a new search chemical that is used by different chemical study libraries and sample reference for NMR, HPLC, FTIPR and GC analysis. The chemists can also use this compound as a reagent. Apart from its dietary and other benefits, it’s also beneficial for sex life. But how? Let’s shed some light over it.
Effects of Acetildenafil
The Acetildenafil improves libido as it increases blood flow to sexual organs. This helps to improve the sex drive. The problem is, it’s not very noticeable, but this compound doesn’t help to achieve and maintain harder erections. People who take this compound reported had erections time from time for 2 to 3 days with minimum vasodilation. Acetildenafil is also the analog sildenafil, better say Viagra. The effects of this compound are similar to one of Cialis. Men who take the methylene and MDMA experience temporary erectile dysfunction, and thus, they need to take an aphrodisiac to take part in any sexual activity.
The problem is, the dosage of Acetildenafil is not established at this time. At this moment, it is available in only 5, 10, 20, and even 110 mg tablets. Taken orally, it’s advised to be taken an hour before engaging in any activity. Anything that is too high can lead to uncomfortable erections that often last for more than 24 hours. Keeping this in mind, the first time users are advised to start with a low dosage and build up their tolerance. It is easily available in the market, but you may need to consult with your physician first. 加入受信任的研究化工目錄 遊行 15, 2016 | 研究化學品目錄
Brief Guide to Nifoxipam
Nifoxipam is known as a long lasting psychoactive drug that belongs to the class of Benzodiazepine. This drug is known for its sedative, hypnotic, anxiolytic, anticonvulsant and muscle relaxant effects. It binds to sites on GABAA gamma-Amino Butyric acid receptor.
Classified as seven nitro benzodiazepine, it belongs to the same category as some other hypnotic Nitrobenzodiazepines. These can be Nitrazepam, Nimetazepam, Flurazepam and others. 此外, this drug has potential use for short-term treatment of anxiety, acute seizures, and sedation of hospitalized patients. It is sold online by the research chemical vendors and is only allowed for psychoactive recreational purposes.
At this moment, Nifoxipam remains in a gray area compound in most parts of the world. Its legality in any county is not verified but people can be charged with its possession under different circumstances.
Belonging to Benzodiazepine class, 該 Nifoxipam contains a benzene ring fused to diazepine ring that is a seven-membered ring with two nitrogen constituents located right at R1 and R4. 此外, Nifoxipam is the active metabolite of flunitrazepam. Benzyl ring of Nifoxipam is substituted at R7 with the nitro group of NO2 AR2 fluorine-substituted phenyl ring that is bound to the structure of R5. Adding up, Nifoxipam contains an OH- group which is substituted R3. The Nifoxipam also has an oxygen group that doubles which is bonded with R2 of the diazepine ring to make a ketone. The oxygen substation of R2 is shared with the Benzodiazepine drugs with Suffix azepam. As with Flunitrazepam, Nifoxipam is insoluble in water but adding hydroxyl can make it a bit soluble.
The Benzodiazepine produces a broad range of effects as it binds to the receptor site and magnifies efficiency with effects of neurotransmitter gamma amino butyric acid by acting on its receptors. This site is the most beneficial inhibitory receptor inside the brain, and therefore, modulation results in sedating of Nifoxipam on the nervous system.
The effects of Nifoxipam are stated as below; these are based on the subjective effects index and persona experiences of subjects. The listed effects rarely occurred and for once only. However heavy dosage can often lead to serious circumstances.
- Control Loss of Motor
- Respiratory Depression
- Muscle Relaxation
The cognitive effects of Nifoxipam easily break into different components that intensify proportional to dosage. The general head space of this compound is described as one of intense sedation and with decreased inhibition, it also has a lot of depressant cognitive effects.
- Compulsive Redosing
- Delusions of Sobriety
- Information Processing Suppression
- Though Deceleration
- Anxiety Suppression
The Paradoxical reactions are increased seizures, aggression, increased anxiety, violent behavior, impulse control loss, irritability and even suicidal behavior. Such effects take place with great frequency in recreational abusers, people who are affected by some mental disorders or children and patients with high dosage regime. The lethal dose of Nifoxipam remains unestablished, but it has a large therapeutic index with a margin of safety.
加入受信任的研究化工目錄 遊行 15, 2016 | 研究化學品目錄
3F-苯甲嗎啉 為更好地為 2-3 氟苯基-3-甲基嗎啉和苯甲嗎啉的氟芬美曲秦類似物. 苯甲嗎啉本身是由苯乙胺骨幹的化合物.
3 FPM以固體粉末和白色結晶的形式提供. 它是易溶於有機溶劑，如DMF, DCM, DMSO, 甲醇, 和乙醇. 這可以用任何惰性氣體來執行. 乙醇溶解度 12 每毫升毫克，而DMF和DMSO都是 16 每毫克ML.
它的苯乙胺各種短暫的興奮劑藥物. 它沒有以前人類使用歷史 2014. 隨著它的影響, 它被認為是微妙的，當與其他興奮劑相比，. 它被廣泛認為其造成少緊張的能力, 欣快症, 相比於安非他明藥物和失眠.
它用作消遣性藥物在許多國家. 3F-苯甲嗎啉 獲好評其誘導欣快其復發性虐待潛在能力. 它規定了精神疾病和肥胖.
這是從一個知名的化學試劑植根. 它擁有苯乙胺骨架. 其中主要差異 3F-苯甲嗎啉 因為它帶有 3 氟基團鍵合至其母體分子. 自推出, 它總是有一個不可預知的實驗室行為.
但相比於其它化合物分享其結構, 3 FPM起著神經遞質的調節具有重要作用與血清素和多巴胺降低和去甲腎上腺素值的強大親和力.
這種化合物很多名字認可; 它具有PAL-593的專利標記，而它具有的分子量 195 克/摩爾. 它表現為在室溫下為結晶性粉末，使得它比較理想的運輸和檢測的任何實驗室. 現在它被簡單地描述為一種有效的模擬，其目的是中樞神經.
它可以釋放的化學信使在大腦. 這些信使被歸類為去甲腎上腺素和多巴胺. 它是未知如何 3F-苯甲嗎啉 能抑制中心在其可控制食慾的下丘腦. 根據已公佈的一些老的研究有助於提供一些證據表明， 3-FPM 可有效抑制食慾.
是, 它促進了大家減肥, 尤其是兒童. 仍然, 這些被禁止在一些國家. 3F-苯甲嗎啉 是不是經常被規定為濫用其潛力. 此外, 有發表的一項研究，明確指出其用戶發展到了抑制食慾作用的阻力，這對減肥沒有服藥數週後下降.
在早期的研究 3F-苯甲嗎啉 顯示了其作為它的能力釋放多巴胺和去甲腎上腺素的媒介. 這種藥物被認為是一些國家進行研究的原因買, 但它主要被取締. 作為3FPM的核心仍然是苯乙胺, 它被認為是導致一些副作用.
以 3F-苯甲嗎啉 在日常可能會導致 加入受信任的研究化工目錄 遊行 14, 2016 | 研究化學品目錄
1P-LSD, 短缺 1 丙麥角酰二乙胺是致幻, 迷幻藥物屬於家庭lysergamide的. 這種物質幾乎沒有人使用的歷史. 這種物質從未報導過任何正式的科學文獻使它不明就裡的公眾和學者.
令人驚訝的是在結構上類似於LSD和ALD 52 這表明它具有相同的效果曲線，以及. 隨著研究的不足與此相關的物質, 每與此相關的藥物的藥理學參數完全根據其結構和主觀效果不是來自其他這樣lysergamides不同.
在年初的幾個月 2015, 1P-LSD 得到了它的法律替代LSZ和LSD, 這個項目是通過在線化學品供應商誰是賣它上市. 該化合物為主要銷售吸墨紙表標籤. 它被標榜為研究化學，使得它很容易把它賣掉法律, 雖然它被出售供人食用
根據其分子結構, 它屬於lysergamide家庭. 這是很類似於LSD, 並且已經命名為綁定到多環的吲哚基的氮其丙酰基. 丙酰基包括綁定到氨基羰基的鏈. 1P-LSD 包含功能綁定到其喹諾酮雙環基團的雙環六氫吲哚的多環基團. 在碳 9 喹啉, 在N-二乙基甲酰胺變得界.
它充當的部分激動劑 5 HT2A. 迷幻的效果來自於療效5HT2A受體. 這種互動的作用，以及如何將這些結果在迷幻的經驗始終保持難以捉摸.
此外, 它被推理 1P-LSD 是藥到LS. 這只能說明 35% 在小鼠LDS的效力. 該LSD與LC-MS的幫助下檢測時 1P-LSD 在人血清中溫育. 這意味著 1P-LSD 不僅不充當LSD也是一種藥, 它直接充當反對它自己的權利血清素受體.
主觀影響 1P-LSD 類似於結構上與它. 差異是微不足道的是可以忽略的，彼此幾乎沒有區別. 如在比較於其他致幻包括LS和脫磷酸裸蓋菇素, 該 1P-LSD 經證實有必要更加刺激和快節奏的，當涉及到特定類型的物理和認知的影響. 效果列出了基於主觀影響指數，部分科目的親身經歷打擊. 上市效應很少發生，只有一次. 但是如果劑量重, 它可能會導致嚴重的情況下.
聽覺效果 加入受信任的研究化工目錄 遊行 14, 2016 | 研究化學品目錄
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