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acetildenafil Effects

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Hvad er acetildenafil og dens virkninger

Det acetildenafil, også kendt som Hongdenafil defineres som en strukturel analog af Viagra. Ifølge undersøgelser, har det vist sig, at acetildenafil virker som en inhibitor for PDE5, ligesom Viagra. Faktum er, denne forbindelse er en fantastisk tilføjelse til mennesker, der studerer effekten af ​​Viagra. Imidlertid, acetildenafil er endnu ikke godkendt til nogen form for Vivo (indersiden af ​​en levende organisme) forskning. På grund af at det har en stærk kemisk lighed med Viagra, det binder på lignende måder til receptorer in vitro (uden for en levende organisme).

Abstrakt

Den analoge acetildenafil blev først opdaget som en ekstrakt af forblandet bulkpulver. Som historien går, det var hensigten at være indkapslet og mærkes som et diætetisk produkt. Dets struktur blev analyseret ved forskellige analyser, såsom NMR, HR-ESI, FRK, ESI-MSN og endda FTIR Analyser. På grund af inddragelse af hydroxylgruppen i ace Iden fil, den detekterede forbindelse blev kaldt Hydroxyacetildenafi.

Hvad er det bruges til?

Det acetildenafil er strengt til forskningsformål i øjeblikket. Ifølge forskning, har det vist sig, at acetildenafil kan bruges sammen med andre PDE5-hæmmere, herunder sildenafil, så længe hjemmekontoret licens bestemt for det. Den kompetitive ligand binding assays kan udføres ved hjælp af denne forbindelse for at undersøge dets affinitet.

De løsninger, der indeholder cGMP specifik phosphodiesterase type 5 kan anvendes til bestemmelse af effekt og bindingsstedet profil acetildenafil. Den vifte af in vitro-muligheder forskning findes for romanen hæmmer.

Det acetildenafil er en ny søgning kemikalie, der bruges af forskellige kemisk undersøgelse biblioteker og prøve henvisning til NMR, HPLC, FTIPR og GC-analyse. De kemikere kan også bruge denne forbindelse som et reagens. Bortset fra dens diætetiske og andre fordele, det er også gavnligt for sexliv. Men hvordan? Lad os kaste lys over det.

Effekter af acetildenafil

Det acetildenafil forbedrer libido da det øger blodtilførslen til kønsorganerne. Dette hjælper til at forbedre sexlyst. Problemet er, det er ikke meget mærkbar, men dette stof hjælper ikke at opnå og opretholde hårdere erektioner. Folk, der tager dette stof rapporteret havde erektioner tid fra tid til 2 til 3 dage med minimum vasodilation. acetildenafil er også den analoge sildenafil, bedre sige Viagra. Virkningerne af denne forbindelse svarer til en af ​​Cialis. Mænd, der tager methylen og MDMA erfaring midlertidig erektil dysfunktion, og dermed, de skal tage et afrodisiakum til at deltage i enhver seksuel aktivitet.

Problemet er, doseringen af acetildenafil ikke er etableret på dette tidspunkt. I dette øjeblik, det er tilgængeligt i kun 5, 10, 20, og endda 110 mg tabletter. indtages oralt, det er rådes til at blive taget en time før udøvelse af enhver aktivitet. Alt, hvad der er for høj, kan føre til ubehagelige erektioner, der ofte vare i mere end 24 timer. Holde dette i tankerne, de første gang brugere rådes til at starte med en lav dosis og opbygge deres tolerance. Det er let tilgængelige på markedet, men det kan være nødvendigt at rådføre sig med din læge først.

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Marts 15, 2016 |

Nifoxipam Effects

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Kort guide til Nifoxipam

Nifoxipam er kendt som en langvarig psykofarmaka, der tilhører klassen af ​​Benzodiazepiner. Dette stof er kendt for sin beroligende, hypnotisk, angstdæmpende, antikonvulsive og muskelafslappende virkninger. Det binder til sites på GABAA gamma-aminosmørsyre receptor.

Klassificeret som syv nitro benzodiazepin, det hører til samme kategori som nogle andre hypnotiske Nitrobenzodiazepines. Disse kan være nitrazepam, Nimetazepam, Flurazepam og andre. i øvrigt, dette stof har potentiel anvendelse til kortvarig behandling af angst, akutte anfald, og sedation af indlagte patienter. Det sælges online af forsknings- kemiske leverandører og er kun tilladt for psykoaktive rekreative formål.

I dette øjeblik, Nifoxipam forbliver i en gråzone forbindelse i de fleste dele af verden. Dens lovlighed i enhver amtet er ikke bekræftet, men folk kan oplades med besiddelse under forskellige omstændigheder.

Kemi

Tilhører Benzodiazepiner klasse, det Nifoxipam indeholder en benzenring kondenseret til diazepin ring, der er en syv-leddet ring med to nitrogenatomer bestanddele beliggende lige ved R1 og R4. i øvrigt, Nifoxipam er den aktive metabolit af flunitrazepam. Benzyl ring af Nifoxipam er substitueret i R7 med nitrogruppen af ​​NO2 AR2 fluor-substitueret phenylring som er bundet til strukturen af ​​R5. Tilføjelse op, Nifoxipam indeholder en OH- gruppe, der er substitueret R3. Det Nifoxipam har også et oxygen-gruppe, der fordobler som er bundet med R2 i diazepinringen at gøre en keton. Den ilt understation af R2 deles med Benzodiazepiner lægemidler med Suffix azepam. Som med flunitrazepam, Nifoxipam er uopløseligt i vand, men tilføjer hydroxyl kan gøre det lidt opløselig.

Farmakologi

Benzodiazepinen producerer en lang række effekter, da det binder til receptorstedet og forstørrer effektivitet med virkningerne af neurotransmitter Gaba ved at indvirke på dens receptorer. Dette site er den mest gavnlige hæmmende receptor i hjernen, og derfor, resultater graduering i beroligende af Nifoxipam på nervesystemet.

subjektive virkninger

Virkningerne af Nifoxipam er angivet som nedenfor; disse er baseret på subjektive virkninger indeks og persona erfaringer emner. De anførte effekter sjældent forekommet, og for kun én gang. Men tung dosis kan ofte føre til alvorlige omstændigheder.

  • Fysiske effekter
  • sedation
  • Kontrol Tab af Motor
  • svimmelhed
  • Respiratorisk depression
  • muskel Afslapning

kognitive virkninger

De kognitive virkninger af Nifoxipam nemt bryde ind forskellige komponenter, som intensivere proportional med dosis. Den generelle head space af denne forbindelse er beskrevet som en af ​​intens sedation og med nedsat inhibering, det har også en masse depressive kognitive virkninger.

  • disinhibition
  • Euphoria
  • Amnesi
  • compulsive Gentagelse af dosis
  • Vrangforestillinger om Ædruelighed
  • Information Processing Suppression
  • Selvom deceleration
  • Angst Suppression

paradoksale virkninger

Det paradoksale reaktioner er øget anfald, aggression, øget angst, voldelig adfærd, impuls kontrol med tab af, irritabilitet og endda selvmordsadfærd. Sådanne virkninger finde sted med stor hyppighed i rekreative misbrugere, mennesker, der er berørt af nogle psykiske lidelser eller børn og patienter med høj dosering regime. Den dødelige dosis af Nifoxipam forbliver ikke etableret, men det har en stor terapeutisk indeks med en sikkerhedsmargin.

 

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Marts 15, 2016 |

3-FPM Effects

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Introduction to 3F-Phenmetrazine: Everything You Need to Know

3F-Phenmetrazine is better known as 2-3 fluorophenyl-3-methymorpholine and fluoro phenmetrazine analogue of Phenmetrazine. Phenmetrazine is itself a compound that consists of Phenethylamine backbone.

The 3-FPM is provided in solid powder and white crystalline form. It’s easily soluble in organic solvents such as DMF, DCM, DMSO, methanol, and ethanol. This can be executed with any inert gas. The ethanol solubility is 12 mg per ml while the DMF and DMSO are 16 mg per ML.

It’s a short-lived stimulant drug of Phenethylamine variety. It has no history of human usage before 2014. With its effects, it’s considered to be subtle when compared with other stimulants. It’s widely regarded for its ability to cause less nervousness, euphoria, and insomnia as compared to the amphetamine drugs.

It’s used as recreational drugs in many countries. 3F-Phenmetrazine is well received for its ability to induce euphoria with its potential for recurrent abuse. It’s prescribed for mental illness and obesity.

Chemical Details

This is rooted from a well-known chemical agent. It possesses Phenethylamine skeleton. The major difference with 3F-Phenmetrazine as it comes with 3 Fluoro group bonded to its parent molecule. Since the introduction, it always had an unpredictable lab behavior.

But as compared to other compounds sharing its structure, 3 FPM plays an important role in the regulation of neurotransmitter with a powerful affinity for serotonin and lower dopamine and noradrenaline value.

This compound is recognized under many names; it has the patent mark of PAL-593 while it possesses the molecular mass of 195 g/mol. It appears as a crystalline powder at room temperature that makes it quite ideal for shipping and testing in any lab. Right now it is simply described as a potent simulated which is aimed at central nervous.

Appetite Suppressant

It can release the chemical messengers in the brain. These messengers are classified as Norepinephrine and Dopamine. It is unknown how 3F-Phenmetrazine can inhibit center in the hypothalamus which can control the appetite. According to some old studies published helps to provide some evidence that 3-FPM is effective for appetite suppression.

Yes, it promotes weight loss for everyone, especially children. Still, these are banned in some countries. 3F-Phenmetrazine is not often prescribed for its potential of abuse. i øvrigt, there was a study published that clearly states its user developed a resistance to its appetite suppressant effects and this the weight loss decreases after few weeks of not taking the drugs.

Legal Status

The early studies on 3F-Phenmetrazine shows its ability to act as it releases a medium of dopamine and norepinephrine. This drug is considered to be bought by some countries for research reasons, but it’s mostly banned. As the core of 3FPM remains Phenethylamine, it is believed to be the cause some side effects.

Pros

The Drug as the following positive effects

  • Clear Headedness
  • Improved Mood Swings
  • Better Socializing
  • Increased Empathy
  • Energetic Feeling
  • Improves awareness and alertness
  • Improves focus
  • Lose weight
  • Improves overall mental concentration

Cons

Taking 3F-Phenmetrazine on daily routine can cause

  • Stinging of Nose
  • Sniffle
  • Numbness and coldness of extremities
  • Jaw Tension
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Marts 14, 2016 |

Effects of 1p-LSD

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Brief intro to 1p-LSD

1p-LSD, short for 1 Propionyl Lysergic Acid Diethylamide is the hallucinogenic, psychedelic drug that belongs to the family of lysergamide. This substance has almost no history of human use. This substance has never been reported in any formal scientific literature making it unknown to the public and the academics.

Surprisingly it is structurally similar to LSD and ALD 52 which suggest it has an identical effect profile as well. With the lack of research related to this substance, every argument related to the pharmacology of this drug is completely according to its structure and the subjective effect that are not different from other such lysergamides.

In the early months of 2015, 1p-LSD got its legal alternative LSZ and LSD, and it was marketed through online chemical vendors who were selling it. This compound as mainly sold in blotter sheet tabs. It was marketed as a research chemical that made it easy to sell it legal, although it was sold for human consumption

Kemi

According to its molecular structure, it belongs to lysergamide family. It is quite analogous to LSD, and it has been named for its propionyl group that is bound to the nitrogen of polycyclic indole group. The propionyl consists of carbonyl chain that is bound to an amino group. 1p-LSD contains a polycyclic group that features the bicyclic Hexahydro indole bound to its quinolone bicyclic group. At carbon 9 of quinoline, the n-diethyl carboxamide becomes bound.

Right now it is in the grey market area that makes its purchase a bit unsafe.

Farmakologi

It acts as the partial agonist of 5 HT2A. Psychedelic effects come from efficacy at 5HT2A receptors. The role of such interactions and how these result in psychedelic experience always remain elusive.

i øvrigt, it has been theorized that 1p-LSD is a prodrug to LS. It shows only 35% potency of LDS in mice. The LSD is detected with the help of LC-MS when the 1p-LSD is incubated in Human Serum. This means that 1p-LSD doesn’t only acts as a prodrug for LSD but also, it directly acts as serotonin receptor against its very own rights.

subjektive virkninger

The subjective effects of 1p-LSD are similar to those structurally related to it. The differences are minuscule that are negligible and virtually indistinguishable from each other. As comparing to other psychedelics which includes LS and Psilocin, det 1p-LSD proves to be even more stimulating and fast paced when it comes to a specific type of its physical and cognitive effects. The effects are listed blow that are based on the subjective effects index and personal experience of some subjects. The listed effects rarely occur and only once. However if the dosage is heavy, it can lead to severe cases.

Fysiske effekter

  • Tactile Sensations
  • Stimulation
  • Bodily controlled enhancement
  • Nausea
  • Tactile improved
  • Pupil Dilation
  • Increase heart rate

kognitive virkninger

  • Current mind state enhancement
  • Thought acceleration
  • Novelty enhancement
  • Immersion enhancement
  • Time distortion
  • Ego death
  • Mindfulness
  • Thought loops
  • Delusions
  • Feeling interdepent opposites
  • Conceptual thinking
  • Self-design feeling
  • Wakefulness
  • Creativity enhancement
  • Though disorganization
  • Spiritual enhancement
  • Personal bias enhancement

Auditory Effects

  • Distortions
  • Hallucination
  • Enhancement
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Marts 14, 2016 |

Research Chemical Suppliers

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Research Chemical Suppliers and Vendors

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Trusted Research Chemical Leverandører

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November 23, 2015 |

Research Chemical Suppliers

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Research Chemicals Suppliers Directory

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