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Acetildenafil Effects

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What is Acetildenafil and its Effects

The Acetildenafil, also known as Hongdenafil is defined as a structural analogue of Viagra. According to studies, it has been found out that Acetildenafil acts as a PDE5 inhibitor, just like Viagra. The fact is, this compound is a great addition to people who are studying effects of Viagra. However, Acetildenafil is not yet licensed for any form of Vivo (inside of a living organism) research. Due to the fact it has a strong chemical resemblance to Viagra, it binds in similar ways to receptors in Vitro (outside of a living organism).

Abstract

The analogue of Acetildenafil was first discovered as an extract of pre-mixed bulk powder. As the story goes, it was intended to be encapsulated and labeled as a dietary product. Its structure was analyzed by different analyses such as NMR, HR-ESI, MS, ESI-Msn and even FTIR Analyses. Owing to the inclusion of hydroxyl group in ace iDEN fil, the detected compound was called Hydroxyacetildenafi.

What is it used for?

The Acetildenafil is strictly for research purposes at the moment. According to research, it has been found that Acetildenafil can be used in conjunction with other PDE5 inhibitors including Sildenafil as long as home office license is held for it. The competitive ligand binding assays can be performed using this compound to learn about its affinity.

The solutions that contain cGMP specific phosphodiesterase type 5 can be used for determination of efficacy and binding site profile of Acetildenafil. The array of in vitro research opportunities exists for the novel inhibitor.

The Acetildenafil is a new search chemical that is used by different chemical study libraries and sample reference for NMR, HPLC, FTIPR and GC analysis. The chemists can also use this compound as a reagent. Apart from its dietary and other benefits, it’s also beneficial for sex life. But how? Let’s shed some light over it.

Effects of Acetildenafil

The Acetildenafil improves libido as it increases blood flow to sexual organs. This helps to improve the sex drive. The problem is, it’s not very noticeable, but this compound doesn’t help to achieve and maintain harder erections. People who take this compound reported had erections time from time for 2 to 3 days with minimum vasodilation. Acetildenafil is also the analog sildenafil, better say Viagra. The effects of this compound are similar to one of Cialis. Men who take the methylene and MDMA experience temporary erectile dysfunction, and thus, they need to take an aphrodisiac to take part in any sexual activity.

The problem is, the dosage of Acetildenafil is not established at this time. At this moment, it is available in only 5, 10, 20, and even 110 mg tablets. Taken orally, it’s advised to be taken an hour before engaging in any activity. Anything that is too high can lead to uncomfortable erections that often last for more than 24 hours. Keeping this in mind, the first time users are advised to start with a low dosage and build up their tolerance. It is easily available in the market, but you may need to consult with your physician first.

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març 15, 2016 |

Nifoxipam Effects

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Brief Guide to Nifoxipam

Nifoxipam is known as a long lasting psychoactive drug that belongs to the class of Benzodiazepine. This drug is known for its sedative, hypnotic, anxiolytic, anticonvulsant and muscle relaxant effects. It binds to sites on GABAA gamma-Amino Butyric acid receptor.

Classified as seven nitro benzodiazepine, it belongs to the same category as some other hypnotic Nitrobenzodiazepines. These can be Nitrazepam, Nimetazepam, Flurazepam and others. d'altra banda, this drug has potential use for short-term treatment of anxiety, acute seizures, and sedation of hospitalized patients. It is sold online by the research chemical vendors and is only allowed for psychoactive recreational purposes.

At this moment, Nifoxipam remains in a gray area compound in most parts of the world. Its legality in any county is not verified but people can be charged with its possession under different circumstances.

química

Belonging to Benzodiazepine class, la Nifoxipam contains a benzene ring fused to diazepine ring that is a seven-membered ring with two nitrogen constituents located right at R1 and R4. d'altra banda, Nifoxipam is the active metabolite of flunitrazepam. Benzyl ring of Nifoxipam is substituted at R7 with the nitro group of NO2 AR2 fluorine-substituted phenyl ring that is bound to the structure of R5. Adding up, Nifoxipam contains an OH- group which is substituted R3. The Nifoxipam also has an oxygen group that doubles which is bonded with R2 of the diazepine ring to make a ketone. The oxygen substation of R2 is shared with the Benzodiazepine drugs with Suffix azepam. As with Flunitrazepam, Nifoxipam is insoluble in water but adding hydroxyl can make it a bit soluble.

farmacologia

The Benzodiazepine produces a broad range of effects as it binds to the receptor site and magnifies efficiency with effects of neurotransmitter gamma amino butyric acid by acting on its receptors. This site is the most beneficial inhibitory receptor inside the brain, and therefore, modulation results in sedating of Nifoxipam on the nervous system.

efectes subjectius

The effects of Nifoxipam are stated as below; these are based on the subjective effects index and persona experiences of subjects. The listed effects rarely occurred and for once only. However heavy dosage can often lead to serious circumstances.

  • efectes físics
  • Sedation
  • Control Loss of Motor
  • Dizziness
  • Respiratory Depression
  • Muscle Relaxation

efectes cognitius

The cognitive effects of Nifoxipam easily break into different components that intensify proportional to dosage. The general head space of this compound is described as one of intense sedation and with decreased inhibition, it also has a lot of depressant cognitive effects.

  • Disinhibition
  • Euphoria
  • Amnesia
  • Compulsive Redosing
  • Delusions of Sobriety
  • Information Processing Suppression
  • Though Deceleration
  • Anxiety Suppression

Paradoxical Effects

The Paradoxical reactions are increased seizures, aggression, increased anxiety, violent behavior, impulse control loss, irritability and even suicidal behavior. Such effects take place with great frequency in recreational abusers, people who are affected by some mental disorders or children and patients with high dosage regime. The lethal dose of Nifoxipam remains unestablished, but it has a large therapeutic index with a margin of safety.

 

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març 15, 2016 |

3-FPM Effects

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Introduction to 3F-Phenmetrazine: Everything You Need to Know

3F-Phenmetrazine is better known as 2-3 fluorophenyl-3-methymorpholine and fluoro phenmetrazine analogue of Phenmetrazine. Phenmetrazine is itself a compound that consists of Phenethylamine backbone.

The 3-FPM is provided in solid powder and white crystalline form. It’s easily soluble in organic solvents such as DMF, DCM, DMSO, methanol, and ethanol. This can be executed with any inert gas. The ethanol solubility is 12 mg per ml while the DMF and DMSO are 16 mg per ML.

It’s a short-lived stimulant drug of Phenethylamine variety. It has no history of human usage before 2014. With its effects, it’s considered to be subtle when compared with other stimulants. It’s widely regarded for its ability to cause less nervousness, euphoria, and insomnia as compared to the amphetamine drugs.

It’s used as recreational drugs in many countries. 3F-Phenmetrazine is well received for its ability to induce euphoria with its potential for recurrent abuse. It’s prescribed for mental illness and obesity.

Chemical Details

This is rooted from a well-known chemical agent. It possesses Phenethylamine skeleton. The major difference with 3F-Phenmetrazine as it comes with 3 Fluoro group bonded to its parent molecule. Since the introduction, it always had an unpredictable lab behavior.

But as compared to other compounds sharing its structure, 3 FPM plays an important role in the regulation of neurotransmitter with a powerful affinity for serotonin and lower dopamine and noradrenaline value.

This compound is recognized under many names; it has the patent mark of PAL-593 while it possesses the molecular mass of 195 g/mol. It appears as a crystalline powder at room temperature that makes it quite ideal for shipping and testing in any lab. Right now it is simply described as a potent simulated which is aimed at central nervous.

Appetite Suppressant

It can release the chemical messengers in the brain. These messengers are classified as Norepinephrine and Dopamine. It is unknown how 3F-Phenmetrazine can inhibit center in the hypothalamus which can control the appetite. According to some old studies published helps to provide some evidence that 3-FPM is effective for appetite suppression.

Yes, it promotes weight loss for everyone, especially children. Still, these are banned in some countries. 3F-Phenmetrazine is not often prescribed for its potential of abuse. d'altra banda, there was a study published that clearly states its user developed a resistance to its appetite suppressant effects and this the weight loss decreases after few weeks of not taking the drugs.

Legal Status

The early studies on 3F-Phenmetrazine shows its ability to act as it releases a medium of dopamine and norepinephrine. This drug is considered to be bought by some countries for research reasons, but it’s mostly banned. As the core of 3FPM remains Phenethylamine, it is believed to be the cause some side effects.

Pros

The Drug as the following positive effects

  • Clear Headedness
  • Improved Mood Swings
  • Better Socializing
  • Increased Empathy
  • Energetic Feeling
  • Improves awareness and alertness
  • Improves focus
  • Lose weight
  • Improves overall mental concentration

Cons

Taking 3F-Phenmetrazine on daily routine can cause

  • Stinging of Nose
  • Sniffle
  • Numbness and coldness of extremities
  • Jaw Tension
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març 14, 2016 |

Efectes de 1p-LSD

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Breu introducció a 1p-LSD

1p-LSD, abreviatura de 1 La propionil Dietilamida de l'àcid lisèrgic és el al·lucinogen, drogues psicodèliques que pertany a la família de lisergamida. Aquesta substància no té gairebé cap història d'ús humà. Aquesta substància no s'ha reportat en cap literatura científica formal pel que és desconegut per al públic i els acadèmics.

Sorprenentment, s'és estructuralment similar a LSD i ALD 52 que suggereixen que té un perfil d'efecte idèntic, així. Amb la falta d'investigacions relacionades amb aquesta substància, cada argument relacionat amb la farmacologia d'aquest fàrmac està completament d'acord amb la seva estructura i l'efecte subjectiu que no són diferents d'altres tals lysergamides.

En els primers mesos de 2015, 1p-LSD va aconseguir el seu LSZ alternativa legal i l'LSD, i es comercialitza a través de proveïdors en línia químics que estaven venent el. Aquest compost es ven com principalment en etiquetes de full de paper secant. Es comercialitza com un producte químic de recerca que fa que sigui fàcil de vendre que sigui legal, tot i que va ser venut per al consum humà

química

D'acord amb la seva estructura molecular, pertany a la família lisergamida. És bastant similar a l'LSD, i s'ha anomenat així pel seu grup propionilo que està unit al nitrogen del grup indol policíclic. La propionil consisteix en cadena de carbonil que està unit a un grup amino. 1p-LSD conté un grup policíclic que compta amb el indol hexahidro bicíclic unit al seu grup bicíclic quinolona. en el carboni 9 de quinolina, la carboxamida N-dietil arriba a unir-se.

En aquest moment es troba a la zona del mercat gris que fa que la compra d'una mica insegur.

farmacologia

Actua com el agonista parcial 5 HT2A. efectes psicodèlics provenen d'eficàcia en els receptors 5HT2A. El paper d'aquestes interaccions i com aquests donen lloc a l'experiència psicodèlica sempre sent difícil d'assolir.

d'altra banda, s'ha teoritzat que 1p-LSD és un profàrmac a LS. només mostra 35% potència de LDS en ratolins. El LSD és detectada amb l'ajuda de CL-EM quan el 1p-LSD s'incuba en sèrum humà. Això significa que 1p-LSD no només actua com un profàrmac per l'LSD sinó també, directament actua com a receptor de la serotonina en contra dels seus propis drets.

efectes subjectius

Els efectes subjectius de 1p-LSD són similars als relacionats estructuralment a ella. Les diferències són minúscules que són insignificants i virtualment indistingibles entre si. Com a comparació amb altres psicodèlics que inclou LS i psilocina, la 1p-LSD resulta ser de ritme encara més estimulant i ràpid quan es tracta d'un tipus específic dels seus efectes físics i cognitius. Els efectes es cop que es basa en l'índex d'efectes subjectius i experiència personal d'alguns subjectes que s'indiquen. Els efectes esmentats ocorren rarament i només una vegada. No obstant això, si la dosi és pesat, que pot donar lloc a casos greus.

efectes físics

  • Les sensacions tàctils
  • estímul
  • millora controlada Corporals
  • nàusea
  • tàctil millorada
  • dilatació de la pupil·la
  • Augmentar el ritme cardíac

efectes cognitius

  • millora l'estat mental actual
  • acceleració pensament
  • millora de la novetat
  • millora de la immersió
  • la distorsió del temps
  • la mort de l'ego
  • L'atenció plena
  • pensat bucles
  • il·lusions
  • Sentint oposats interdepent
  • El pensament conceptual
  • sensació d'auto-disseny
  • desvetllament
  • millora de la creativitat
  • Tot i la desorganització
  • millora espiritual
  • millora prejudicis personals

efectes auditius

  • distorsions
  • al·lucinació
  • realç
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març 14, 2016 |

Research Chemical Suppliers

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Research Chemical Suppliers and Vendors

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Join the best research chemical to get the chemicals safely and secure with just a click. You have to follow the simple research procedure to become a member of the trusted research chemical suppliers directory. We just need your email ID and we will send you the link to register to our website.

Most of our beloved visitors are here to look for chemicals and trusted research chemical suppliers, so we also provide you with a list of many research chemical suppliers. Most of the research chemical suppliers are from UK and we supply the research chemicals to the local UK to the USA and parts of Europe.

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November 23, 2015 |

Research Chemical Suppliers

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Research Chemicals Suppliers Directory

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