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Acetildenafil Effects

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What is Acetildenafil and its Effects

The Acetildenafil, also known as Hongdenafil is defined as a structural analogue of Viagra. According to studies, it has been found out that Acetildenafil acts as a PDE5 inhibitor, just like Viagra. The fact is, this compound is a great addition to people who are studying effects of Viagra. However, Acetildenafil is not yet licensed for any form of Vivo (inside of a living organism) research. Due to the fact it has a strong chemical resemblance to Viagra, it binds in similar ways to receptors in Vitro (outside of a living organism).

Abstract

The analogue of Acetildenafil was first discovered as an extract of pre-mixed bulk powder. As the story goes, it was intended to be encapsulated and labeled as a dietary product. Its structure was analyzed by different analyses such as NMR, HR-ESI, MS, ESI-Msn and even FTIR Analyses. Owing to the inclusion of hydroxyl group in ace iDEN fil, the detected compound was called Hydroxyacetildenafi.

What is it used for?

The Acetildenafil is strictly for research purposes at the moment. According to research, it has been found that Acetildenafil can be used in conjunction with other PDE5 inhibitors including Sildenafil as long as home office license is held for it. The competitive ligand binding assays can be performed using this compound to learn about its affinity.

The solutions that contain cGMP specific phosphodiesterase type 5 can be used for determination of efficacy and binding site profile of Acetildenafil. The array of in vitro research opportunities exists for the novel inhibitor.

The Acetildenafil is a new search chemical that is used by different chemical study libraries and sample reference for NMR, HPLC, FTIPR and GC analysis. The chemists can also use this compound as a reagent. Apart from its dietary and other benefits, it’s also beneficial for sex life. But how? Let’s shed some light over it.

Effects of Acetildenafil

The Acetildenafil improves libido as it increases blood flow to sexual organs. This helps to improve the sex drive. The problem is, it’s not very noticeable, but this compound doesn’t help to achieve and maintain harder erections. People who take this compound reported had erections time from time for 2 to 3 days with minimum vasodilation. Acetildenafil is also the analog sildenafil, better say Viagra. The effects of this compound are similar to one of Cialis. Men who take the methylene and MDMA experience temporary erectile dysfunction, and thus, they need to take an aphrodisiac to take part in any sexual activity.

The problem is, the dosage of Acetildenafil is not established at this time. At this moment, it is available in only 5, 10, 20, and even 110 mg tablets. Taken orally, it’s advised to be taken an hour before engaging in any activity. Anything that is too high can lead to uncomfortable erections that often last for more than 24 hours. Keeping this in mind, the first time users are advised to start with a low dosage and build up their tolerance. It is easily available in the market, but you may need to consult with your physician first.

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March 15, 2016 |

Nifoxipam Effects

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Brief Guide to Nifoxipam

Nifoxipam is known as a long lasting psychoactive drug that belongs to the class of Benzodiazepine. This drug is known for its sedative, hypnotic, anxiolytic, anticonvulsant and muscle relaxant effects. It binds to sites on GABAA gamma-Amino Butyric acid receptor.

Classified as seven nitro benzodiazepine, it belongs to the same category as some other hypnotic Nitrobenzodiazepines. These can be Nitrazepam, Nimetazepam, Flurazepam and others. Moreover, this drug has potential use for short-term treatment of anxiety, acute seizures, and sedation of hospitalized patients. It is sold online by the research chemical vendors and is only allowed for psychoactive recreational purposes.

At this moment, Nifoxipam remains in a gray area compound in most parts of the world. Its legality in any county is not verified but people can be charged with its possession under different circumstances.

Chemistry

Belonging to Benzodiazepine class, the Nifoxipam contains a benzene ring fused to diazepine ring that is a seven-membered ring with two nitrogen constituents located right at R1 and R4. Moreover, Nifoxipam is the active metabolite of flunitrazepam. Benzyl ring of Nifoxipam is substituted at R7 with the nitro group of NO2 AR2 fluorine-substituted phenyl ring that is bound to the structure of R5. Adding up, Nifoxipam contains an OH- group which is substituted R3. The Nifoxipam also has an oxygen group that doubles which is bonded with R2 of the diazepine ring to make a ketone. The oxygen substation of R2 is shared with the Benzodiazepine drugs with Suffix azepam. As with Flunitrazepam, Nifoxipam is insoluble in water but adding hydroxyl can make it a bit soluble.

Pharmacology

The Benzodiazepine produces a broad range of effects as it binds to the receptor site and magnifies efficiency with effects of neurotransmitter gamma amino butyric acid by acting on its receptors. This site is the most beneficial inhibitory receptor inside the brain, and therefore, modulation results in sedating of Nifoxipam on the nervous system.

Subjective Effects

The effects of Nifoxipam are stated as below; these are based on the subjective effects index and persona experiences of subjects. The listed effects rarely occurred and for once only. However heavy dosage can often lead to serious circumstances.

  • Physical Effects
  • Sedation
  • Control Loss of Motor
  • Dizziness
  • Respiratory Depression
  • Muscle Relaxation

Cognitive Effects

The cognitive effects of Nifoxipam easily break into different components that intensify proportional to dosage. The general head space of this compound is described as one of intense sedation and with decreased inhibition, it also has a lot of depressant cognitive effects.

  • Disinhibition
  • Euphoria
  • Amnesia
  • Compulsive Redosing
  • Delusions of Sobriety
  • Information Processing Suppression
  • Though Deceleration
  • Anxiety Suppression

Paradoxical Effects

The Paradoxical reactions are increased seizures, aggression, increased anxiety, violent behavior, impulse control loss, irritability and even suicidal behavior. Such effects take place with great frequency in recreational abusers, people who are affected by some mental disorders or children and patients with high dosage regime. The lethal dose of Nifoxipam remains unestablished, but it has a large therapeutic index with a margin of safety.

 

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March 15, 2016 |

3-FPM Effects

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Introduction to 3F-Phenmetrazine: Everything You Need to Know

3F-Phenmetrazine is better known as 2-3 fluorophenyl-3-methymorpholine and fluoro phenmetrazine analogue of Phenmetrazine. Phenmetrazine is itself a compound that consists of Phenethylamine backbone.

The 3-FPM is provided in solid powder and white crystalline form. It’s easily soluble in organic solvents such as DMF, DCM, DMSO, methanol, and ethanol. This can be executed with any inert gas. The ethanol solubility is 12 mg per ml while the DMF and DMSO are 16 mg per ML.

It’s a short-lived stimulant drug of Phenethylamine variety. It has no history of human usage before 2014. With its effects, it’s considered to be subtle when compared with other stimulants. It’s widely regarded for its ability to cause less nervousness, euphoria, and insomnia as compared to the amphetamine drugs.

It’s used as recreational drugs in many countries. 3F-Phenmetrazine is well received for its ability to induce euphoria with its potential for recurrent abuse. It’s prescribed for mental illness and obesity.

Chemical Details

This is rooted from a well-known chemical agent. It possesses Phenethylamine skeleton. The major difference with 3F-Phenmetrazine as it comes with 3 Fluoro group bonded to its parent molecule. Since the introduction, it always had an unpredictable lab behavior.

But as compared to other compounds sharing its structure, 3 FPM plays an important role in the regulation of neurotransmitter with a powerful affinity for serotonin and lower dopamine and noradrenaline value.

This compound is recognized under many names; it has the patent mark of PAL-593 while it possesses the molecular mass of 195 g/mol. It appears as a crystalline powder at room temperature that makes it quite ideal for shipping and testing in any lab. Right now it is simply described as a potent simulated which is aimed at central nervous.

Appetite Suppressant

It can release the chemical messengers in the brain. These messengers are classified as Norepinephrine and Dopamine. It is unknown how 3F-Phenmetrazine can inhibit center in the hypothalamus which can control the appetite. According to some old studies published helps to provide some evidence that 3-FPM is effective for appetite suppression.

Yes, it promotes weight loss for everyone, especially children. Still, these are banned in some countries. 3F-Phenmetrazine is not often prescribed for its potential of abuse. Moreover, there was a study published that clearly states its user developed a resistance to its appetite suppressant effects and this the weight loss decreases after few weeks of not taking the drugs.

Legal Status

The early studies on 3F-Phenmetrazine shows its ability to act as it releases a medium of dopamine and norepinephrine. This drug is considered to be bought by some countries for research reasons, but it’s mostly banned. As the core of 3FPM remains Phenethylamine, it is believed to be the cause some side effects.

Pros

The Drug as the following positive effects

  • Clear Headedness
  • Improved Mood Swings
  • Better Socializing
  • Increased Empathy
  • Energetic Feeling
  • Improves awareness and alertness
  • Improves focus
  • Lose weight
  • Improves overall mental concentration

Cons

Taking 3F-Phenmetrazine on daily routine can cause

  • Stinging of Nose
  • Sniffle
  • Numbness and coldness of extremities
  • Jaw Tension
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March 14, 2016 |

Effects of 1p-LSD

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Brief intro to 1p-LSD

1p-LSD, short for 1 Propionyl Lysergic Acid Diethylamide is the hallucinogenic, psychedelic drug that belongs to the family of lysergamide. This substance has almost no history of human use. This substance has never been reported in any formal scientific literature making it unknown to the public and the academics.

Surprisingly it is structurally similar to LSD and ALD 52 which suggest it has an identical effect profile as well. With the lack of research related to this substance, every argument related to the pharmacology of this drug is completely according to its structure and the subjective effect that are not different from other such lysergamides.

In the early months of 2015, 1p-LSD got its legal alternative LSZ and LSD, and it was marketed through online chemical vendors who were selling it.  This compound as mainly sold in blotter sheet tabs. It was marketed as a research chemical that made it easy to sell it legal, although it was sold for human consumption

Chemistry

According to its molecular structure, it belongs to lysergamide family. It is quite analogous to LSD, and it has been named for its propionyl group that is bound to the nitrogen of polycyclic indole group. The propionyl consists of carbonyl chain that is bound to an amino group. 1p-LSD contains a polycyclic group that features the bicyclic Hexahydro indole bound to its quinolone bicyclic group. At carbon 9 of quinoline, the n-diethyl carboxamide becomes bound.

Right now it is in the grey market area that makes its purchase a bit unsafe.

Pharmacology

It acts as the partial agonist of 5 HT2A. Psychedelic effects come from efficacy at 5HT2A receptors. The role of such interactions and how these result in psychedelic experience always remain elusive.

Moreover, it has been theorized that 1p-LSD is a prodrug to LS. It shows only 35% potency of LDS in mice. The LSD is detected with the help of LC-MS when the 1p-LSD is incubated in Human Serum. This means that 1p-LSD doesn’t only acts as a prodrug for LSD but also, it directly acts as serotonin receptor against its very own rights.

Subjective Effects

The subjective effects of 1p-LSD are similar to those structurally related to it. The differences are minuscule that are negligible and virtually indistinguishable from each other. As comparing to other psychedelics which includes LS and Psilocin, the 1p-LSD proves to be even more stimulating and fast paced when it comes to a specific type of its physical and cognitive effects. The effects are listed blow that are based on the subjective effects index and personal experience of some subjects. The listed effects rarely occur and only once. However if the dosage is heavy, it can lead to severe cases.

Physical Effects

  • Tactile Sensations
  • Stimulation
  • Bodily controlled enhancement
  • Nausea
  • Tactile improved
  • Pupil Dilation
  • Increase heart rate

Cognitive Effects

  • Current mind state enhancement
  • Thought acceleration
  • Novelty enhancement
  • Immersion enhancement
  • Time distortion
  • Ego death
  • Mindfulness
  • Thought loops
  • Delusions
  • Feeling interdepent opposites
  • Conceptual thinking
  • Self-design feeling
  • Wakefulness
  • Creativity enhancement
  • Though disorganization
  • Spiritual enhancement
  • Personal bias enhancement

Auditory Effects

  • Distortions
  • Hallucination
  • Enhancement
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March 14, 2016 |

Research Chemical Suppliers

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Research Chemical Suppliers and Vendors

Buying research chemicals can be hectic at time. If you are looking for trusted research chemical suppliers, you have entered the right place. With the widest range of high quality research chemicals that are offered at the most affordable price, buy research chemicals become the best and the most trusted research chemical suppliers the internet.

We accomplish all the things needed to be called a trusted research chemical supplier. We have a broad range of research chemicals that include the MEXEDRONE POWDER, 3-FPM CRYSTAL, DIPHENIDINE, DUTCH TAN MPA and many more. We assure you for on time delivery, fast delivery of chemicals any day of the week till 3:30pm. We also make sure that the research chemicals are thoroughly tested and then brought into the market to avoid any hazard from it. This makes us the most trusted research chemical suppliers; above all we sell the research chemicals to you at its best price.

Join the best research chemical to get the chemicals safely and secure with just a click. You have to follow the simple research procedure to become a member of the trusted research chemical suppliers directory. We just need your email ID and we will send you the link to register to our website.

Most of our beloved visitors are here to look for chemicals and trusted research chemical suppliers, so we also provide you with a list of many research chemical suppliers. Most of the research chemical suppliers are from UK and we supply the research chemicals to the local UK to the USA and parts of Europe.

There are often complains of chemicals getting mixed up with one another during the time of transportation and delivery. The trusted research chemical suppliers in our directory make sure that all the chemicals supplied by them are separately packed and properly stored in the container to avoid any contact between the chemicals which might alter the results of the experiment conducted with them.

The trusted research chemical suppliers not only help you too purchase the products at minimum price but they give you attractive discounts and deals. You can get more and more research chemicals from us and avail more and more discounts that are offered by us on a weekly basis. You can find number of discounts on the research chemical suppliers list.

Our supplies are not only limited to UK, USA and Europe but we also deliver the research chemicals to other parts of the world too.

Each and every seller in the trusted research chemical suppliers directory is personally checked and is a legitimate supplier of research chemicals. The rules and regulations stated for the selling of research chemicals is followed thoroughly and to avoid any problems with the government.

Buy research chemicals from trusted research chemical suppliers, the product is cheap, legal and completely safe. We have been active in this field for a long time now; have been successful in doing selling research chemicals to lot of peoples around the world. Choosing us for research chemicals will help you to get high quality chemicals and also reliable service.

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Trusted Research Chemical Suppliers

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November 23, 2015 |

Research Chemical Suppliers

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Research Chemicals Suppliers Directory

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November 4, 2015 |
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